2. a. Compound D, Figure 5, can undergo a palladium catalysed cyclisation to give compound E. BugSn Ph OTf Pd(PPh3)4 C25H26 LiCl E D Figure 5 (i) Name the reaction generating compound E from compound D. (ii) Discuss the catalytic cycle for the formation of compound E. (iii) Briefly explain the role of the LiCl additive in Figure 5. (iv) Draw the structure of compound E. [ [ Co

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2. a.
Compound D, Figure 5, can undergo a palladium catalysed cyclisation to give
compound E.
BugSn
Ph
OTf
Pd(PPh3)4
C25H26
LiCl
E
D
Figure 5
(i)
Name the reaction generating compound E from compound D.
(ii) Discuss the catalytic cycle for the formation of compound E.
(iii) Briefly explain the role of the LiCl additive in Figure 5.
(iv) Draw the structure of compound E.
[
[
Co
Transcribed Image Text:2. a. Compound D, Figure 5, can undergo a palladium catalysed cyclisation to give compound E. BugSn Ph OTf Pd(PPh3)4 C25H26 LiCl E D Figure 5 (i) Name the reaction generating compound E from compound D. (ii) Discuss the catalytic cycle for the formation of compound E. (iii) Briefly explain the role of the LiCl additive in Figure 5. (iv) Draw the structure of compound E. [ [ Co
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