A novel new method of peptide synthesis involves formation of an amide bond by reaction of an a-keto acid with an N-alkylhydroxylamine. OH R CO2 R' R R' + CO2 + H2O Draw curved arrows to show the movement of electrons in the following step of the reaction mechanism. Arrow-pushing Instructions X R :0: :O: R' H:OH H-A بد R :O: Nx- R' H2O CO2 A H- (18

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter26: Biomolecules: Amino Acids, Peptides, And Proteins
Section26.SE: Something Extra
Problem 28MP
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A novel new method of peptide synthesis involves formation of an amide bond by reaction of an a-keto acid with an N-alkylhydroxylamine.
OH
R
CO2
R'
R
R'
+ CO2 + H2O
Draw curved arrows to show the movement of electrons in the following step of the reaction mechanism.
Arrow-pushing Instructions
X
R
:0:
:O:
R'
H:OH
H-A
بد
R
:O:
Nx-
R'
H2O CO2 A
H-
(18
Transcribed Image Text:A novel new method of peptide synthesis involves formation of an amide bond by reaction of an a-keto acid with an N-alkylhydroxylamine. OH R CO2 R' R R' + CO2 + H2O Draw curved arrows to show the movement of electrons in the following step of the reaction mechanism. Arrow-pushing Instructions X R :0: :O: R' H:OH H-A بد R :O: Nx- R' H2O CO2 A H- (18
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