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Match the following hypersensitivity reactions with the associated immune response or disease
1. IgE mediated
2. Poison ivy
3. Blood transfusion reaction
4. Associated with autoantigens
5. Immune-complex mediated
6. Allergies (e.g. hay fever)
7. IgG or IgM mediated
8. Cell-mediated
Type I
Type II
Type III
Type IV
Step by step
Solved in 3 steps
- 1. which antibody isotypes is in lowest concentration in serum? a- IGA b- IgD c-IgG d-IgE e- IgM 2. A ruptured spleed was removed from a 37 year old car accident victim. what would be the consequences? a- lack of IgG producing B cells b- lack of IgA producing B cells c- Can't mature T cells d-Lack of IgG producing B cells e- can't activate macrophages1. Pula was feeling ill for a number of months. She experienced myriad of symptoms such as achy joints, a temperature of over 100 degrees, skin rashes especially around the face, persistent lethargy, chest pain and sensitivity to the sun. After a series of test she was told that she has an Autoimmune Disease. Question Analyze the above case study by: a. Explaining what are Autoimmune Diseases and the likely Autoimmune Disease Paula has. b. The possible causative factor and a treatment plan for Paula C. Psychological Disorders that may accompany thisThe following are steps in the cell-mediated inflammatory response. Put them in the correct order. 1. Activated macrophage cells release cytokines. 2. Antigen is engulfed and presented by a macrophage cell w/MHC II complex. 3. The TH1 cell's CD4 protein binds to the MHC II complex. 4. Phagocytosis and inflammation occur. 5. Th1 secrete TNF-alpha and other cytokines which activates the macrophage. A. 3, 4, 1, 2,5 В. 2, 3, 4, 5, 1 C. 3,5, 4, 1, 2 D. 2,3,5, 1, 4
- What scenario best describes an autoimmune reaction? Group of answer choices The destruction of donated red blood cells by the recipient’s immune system The production of antibodies against Streptococcus pyogenes antigen resulting in cross-reaction against an antigen found on heart valves The activation of Mast cells by pollen The production of antibodies against Streptococcus pyogenes resulting in the deposit of antigen-antibodies in the kidney leading to glomerulonephritis1. Match the hypersensitivity reaction with the cause. Type II Type I Type III Type IV A. Sensitized Ag binding to IgE whose Fc region has bound to mast cells B. Small molecules binding to human cells producing structures that look foreign C. Effector T cells specific for sensitized Ag D. IgG bound to small immune complexes formed from soluble proteins 2. Match the drug with their actions. Corticosteroids Epinephrine Antihistamines…Which ONE of the following is TRUE regarding adult T‐cell leukaemia‐lymphoma? Select one: A.The tumour cells have a CD4+ CD25+ phenotype B.It is usually cured with the CHOP chemotherapy regimen C.It is most commonly caused by infection with HIV D.It is commonly associated with hypocalcaemia at presentation
- A 67‐year‐old man with rheumatoid arthritis presents with neutropenia. The blood count shows a mild lymphocytosis with an increased number of cells which express CD3, CD16 and CD57. T cell gene rearrangement study shows a clonal band. Which ONE of the following is the diagnosis in this case? Select one: A.Mycosis fungoides B.Infectious mononucleosis C.Large granular lymphocyte leukaemia D.Chronic lymphocytic leukaemiaTABLE 6 | Correlation between immune markers and age. Marker NCI PAN LCI LP NK activity (lysis %) R Spearman -0.406 -0.305 -0.239 -0.204 -0.016 Р 0.004 0.035 0.101 0.165 0.913 NCI, Neutrophil Chemotaxis Index; PAN, phagocytic activity of neutrophils; LCI, Lymphocyte Chemotaxis Index; LP, lymphocyte proliferation; NK, natural killer. p is the associated value to the corresponding statistical test.Which of the following diseases is not due to autoimmunity?A. rheumatic feverB. systemic lupus erythematosusC. diabetes mellitusD. HIV/AIDS 3. Which of the following is both a phagocyte and an antigen-presenting cell?A. Natural Killer cellB. eosinophilC. neutrophilD. macrophage 4. What is the first line of defence against germs?A. HeartB. SkinC. Brain D. Eyes5.Which organs in your throat trap germs that come in?A. PancreasB. Spleen C. TonsilsD. Liver6. A person is injected with immunoglobulins against hepatitis B. This person has :A. Artificially acquired passive immunityB. Artificially acquired active immunityC. Naturally acquired active immunityD. Naturally acquired passive immunity
- 1. Which of the following statements about CD4+ Th17 cells are true? i. Cannot form T effector memory (TEM) T cell populations ii. Require the master transcription factor RORgammaT for their development iii. Produce effector cytokines IL-17 and IL-22 which help recruit neutrophils and stimulate antimicrobial peptide production iv. Do not require the transcription factor NFAT for IL-2 production downstream of TCR activation v. Important for defense against intracellular bacterial infection only a. i and iii b. ii and v c. ii and iii d. ii, iii, iv e. i, ii, and ivAn 18-month old has been hospitalized several times because of severe recurrent infections with Candida chronic hypocalcemia, and failure to thrive . Flow cytomegalovirus shows a decreased number of peripheral blood lymphocytes reacting with fluoresceinated anti human IgGand decreased number of CD3+ T lymphocytes. Which of the following is the most likely diagnosis. (A) AIDS. (B). Bruton X-linked agammaglobulinemia. (C) Chronic granulomatous disease. (D) Common Variable Hypogammaglobunemia.…Identify the mismatched pair. (Select all that apply.) a. type I hypersensitivity: mast cells, basophils, and eosinophils b. type II hypersensitivity: penicillin allergy c. type III hypersensitivity: modified cell-surface components d. type IV hypersensitivity: CD4 TH1 or CD8 T cells e. type III hypersensitivity: nonhuman therapeutic proteins f. type IV hypersensitivity: modified intracellular human proteins g. type II hypersensitivity: immediate hypersensitivity h. type I hypersensitivity; IgE cross-linking.
