The last step in the synthesis of a series of potential anti-inflammatory agents is shown below (Ar is some arene ring. Thereaction results in the loss of the elements of water (that is, theproduct has two less H's and one less O than the reagent shown).Give the structure of the product and the full, step-by-stepmechanism for its formation.ArArCat. Na omeMe of

Step 1:The product structure is:Ar−(CH2)3−C(=O)−ArThe mechanism involves the following key steps:The…

Answered: The last step in the synthesis of a…

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter16: Chemistry Of Benzene: Electrophilic Aromatic Substitution

Section16.SE: Something Extra

Problem 27VC

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a. Provide the structure of the hydrate of cyclopentanone. b. Provide the major organic product which results when pentanal is subjected to the following sequence of steps: 1. PhMgBr; 2. H3O+; 3. PCC.
Suggest an efficient synthesis for the following transformation: .CI H. The synthesis above can be performed with some combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). KMNO4, A: NAOH, 1) BH3-THF G: 2) H2O2, D: HBr cold NaOH 1) O3; 2) В: DMS E: NaOMe conc. H2SO4, H: heat 1) Hg(OAc)2, C: HBr, ROOR F: H2/Pt H20 2) NABH4 I:
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The second part of the synthesis of 1 involves conversion from compound 5 to compound 8. N. TMSCN condition B reagent C Но- -N. N. BnO > 7 - H* H* "CN ОН Bno OBn 5 8 3a. TMSCN has the structure of (CH3)3 Si-CN and can be considered as an equivalent of cyanide ion, CN-. Deduce the structure of compound 6. 3b. Compound 6 is then converted to compound 8, via compound 7. Draw the structure of 7, condition B and reagent C.
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Chemistry 3. Complete the following reaction scheme. Give all product(s) and indicate major or minor and any relevant stereochemistry. (а) NaOEt heat (b) heat (c) Br NaCN DMF (d) (e) OH H,SO,/H,PO, heat (f) HBr (g) 1) BH. THE 2) H,0, OH (h) 1) Hg(OAC), H-0 2) NaBH, (i) KMNO, NaOH Cold

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