Under aerobic conditions of high ratios of NADH/NAD+ and ATP/ADP, as pyruvate is utilized for itscarbon skeleton, which molecules would you expect to see significant radiolabeling in the liver?Select all that apply.**Please note some molecules contain more details, including not only molecule name, but locationof the label. Pick the options that are accurate for the above situation.Glucose C-2 and C-5Glucose C-1 and C-6Glucose C-2 onlyPyruvate C-1Lactate C-2 for exportCO, from TCA cycle shows some radiolabelLabel is halved over many TCA cyclesOxaloacetateMalate

Glycolysis: The process through which glucose is broken down to create pyruvate in a cell's…

Answered: Under aerobic conditions of high ratios…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Under aerobic conditions of high ratios of NADH/NAD+ and ATP/ADP, as pyruvate is utilized for its carbon skeleton, which molecules would you expect to see significant radiolabeling in the liver? Select all that apply. **Please note some molecules contain more details, including not only molecule name, but location of the label. Pick the options that are accurate for the above situation. O Glucose C-2 and C-5 O Glucose C-1 and C-6 O Glucose C-2 only Pyruvate C-1 Lactate C-2 for export O CO2 from TCA cycle shows some radiolabel Label is halved over many TCA cycles Oxaloacetate O Malate
Under aerobic conditions when glucose is limiting, with high ratios of NADH/NAD+ and ATP/ADP, as carbon-2 radiolabeled pyruvate is utilized for its carbon skeleton, which molecules would you expect to see significant radiolabeling in the liver? Select all that apply. **Please note some molecules contain more details, including not only molecule name, but location of the label. Pick the options that are accurate for the above situation. Glucose C-2 only Label is halved over many TCA cycles Oxaloacetate Glucose C-1 and C-6 Glucose C-2 and C-5 CO2 from TCA cycle shows some radiolabel Lactate C-2 for export Malate Pyruvate C-1
Under aerobic conditions of high ratios of NADH/NAD+ and ATP/ADP, as pyruvate is utilized for its carbon skeleton, which molecules would you expect to see significant radiolabeling in the liver? Select all that apply. **Please note some molecules contain more details, including not only molecule name, but location of the label. Pick the options that are accurate for the above situation. 1. Glucose C2 & C5 2. Glucose C1 & C6 3. Glucose C2 only 4. Pyruvate C1 5. Lactate C2 for export 6.CO2 from TCA cycle shows some radiolabel 7. Label is halved over many TCA cycles 8. Oxaloacetate 9. Malate
In class, I mentioned that fructose is metabolized differently in the liver compared to glucose. Refer to the figure shown below to calculate the number ofATPs you would expect from the metabolism of fructose in the liver. Show your work! Fructokinase Fructose Fructose-1-P АТР ADP Aldolase B Dihydroxy- acetone phosphate Glyceraldehyde АТР Triose kinase Triose phosphate isomerase ADP 4 - Glyceraldehyde-3-P Glycolysis Руruvate Acetyl-CoA Fatty acids and triglycerides
The biosynthesis of vitamin D₂ is a two-step reaction, requiring two types of concerted pericyclic reactions. Draw in the arrows for each step and identify the structure of precalciferol. If an electrocyclic reaction is required, identify if it occurs through a conrotatory or disrotatory reaction. HO H H ergosterol hv precalciferol Cast HO ergocalciferol
Indicate the general type of enzyme that mediates each glycolysis reaction depicted below. (e.g. Transferase, Oxidoreductase, Kinase, Hydrolase, Lyase, or Isomerase) iii. O H Glyceraldehyde-3-phosphate → 1,3-Bisphosphoglycerate H-C-OH + NAD CH₂O-P + P₁ H-O- -C-H Glucose →→ Glucose-6-phosphate H b 0 OH HO OH H-C- 0 -H HO- H ОН H-C-OH + NADH +H+ CH₂O P P ATP ADP 1 H (P-O- -C- H H HO OH 2-Phosphoglycerate → Phosphoenolpyruvate 0 OH H ОН -O~(P) + HOH
Upon digestion of starch, isomaltose (an isomer of maltose), one of its degradation products, is further hydrolyzed into its monosaccharide components prior to intestinal absorption and entry into the glycolysis. Calculate the number of ATP molecules produced from the digestion and complete oxidation of 4 molecules of isomaltose considering the glycerol 3-phosphate shuttle. Answer the following items using numerical value only (e.g. 1, not "1 ATP") which will help you arrive at the final answer for this question. a. Total number of glucose molecules entering glycolysis: b. Total number of pyruvate molecules produced at the end of glycolysis: c. Total number of mitochondrial NADH produced after pyruvate is acted upon by the pyruvate dehydrogenase complex: d. Total number of CO, released right after the pyruvate dehydrogenase complex reaction: e. Total number of acetyl CoA molecules entering the citric acid cycle:
If glucokinase has a higher Km for glucose than does hexokinase, but can only bind to D-glucose, while hexokinase can bind to several hexose sugars (like D-glucose, D-mannose, and D-fructose), then: glucokinase has both a higher affinity and a higher specificity for D-glucose than does hexokinase glucokinase has both a lower affinity and a lower specificity for D-glucose than does hexokinase glucokinase has a higher affinity but a lower specificity for D-glucose than does hexokinase glucokinase has a lower affinity but a higher specificity for D-glucose than does hexokinase all of the above
Which of the following statements are True? Multiple answers: Multiple answers are accepted for this question Select one or more answers and submit. For keyboard navigation. SHOW MORE V If [1-14C) Ribose-S-phosphate is incubated with a mixture of purified transketolase- transaldolase-phosphopentose isomerase-phosphopentose epimerase and glyceraldehyde-3-phosphate Fructose-6-phosphate will be labeled in the 1 and 3 positions. a Starting with Glucose 6-phosphate labelled in carbon number 1 with radioactive carbon and taken through the axidative phase of the Pentose Phosphate Pathway and the first transaldolase reaction gives rise to a 7-carbon intermediate labeled with radioactive carbon in carbon number 1. Avidin is a protein that binds extremely tight to biotin. So avidin would be a potent inhibitor of Acetyl CoA Carboxylase. The two electrons derived from the a-Ketoglutarate Dehydrogenase complex come from dihydrolipoic acid. In Fatty Acid synthesis carbon atoms 15 and 16 of Palmitic…
In relation to Carbamoyl Phosphate Synthetase enzyme, answer the following: A- What are the two isoforms of this enzyme, explain why there are two isoforms? B- What are the clinical manifestations associated with the deficiency of these two enzymes? C- Write down the biochemical reaction and the name of the metabolic pathway that these two isoforms are involved in, and how many ATP is utilized by these two isoforms?
Myristoleic acid is a monounsaturated fatty acid found in small amounts in a variety of foods. Calculate the net ATP yield from the complete β-oxidation of myristoleic acid. The formula of myristoleic acid is shown below (it is assumed that the total ATP production is the same for both saturated and unsaturated fatty acids having the same carbon chain length). CH3-(CH2)3-CHCH-(CH2)7-COOH (Given: The oxidation of one NADH yields 2.5 ATP; the oxidation of one FADH2 yields 1.5 ATP; and the oxidation of one acetyl CoA yields 10 ATP. ) Group of answer choices a. 96 ATP b. 92 ATP c. 94 ATP d. 34 ATP e. 36 ATP
Consider the each of the amino acids in the peptide below. Ala-Ile-Asp-Arg-Gln-Gly-Pro-Gly-Ala-Tyr-Val-Ile-Gln-Leu If all of the amino acids are degraded to yield energy (ATP), explain how many Acetyl CoAs for oxidation to CO2 could be produced from this peptide. note: Do not make glucose at the beginning, however converting the TCA intermediates into molecules in the glycolytic pathway for optimal Acetyl CoA production is allowed. Be sure to show clearly which pathway will the Acetyl CoA enter (to yield ATP ultimately) under such condition

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