Using the data provided in the table, the estimated p50 for myoglobin is mmHg and the fraction saturation of myoglobin at 30mmHg is
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- The following data describe the binding of oxygen to human myoglobin. Posygen (mm Hg) Percent Saturation 0.5 16.1 2.0 27.7 3.0 53.5 4.0 60.5 6.0 69.7 8.0 75.4 12.0 82.1 20.0 88.5 From these data the approximate P50 (mm Hg) value is: A. 1.0 В. 1.4 С. 1.9 D. 2.6 Е. 3.2 F. 3.5 G. 3.7 Н. 3.9 I. 4.0HbR is reported to have P50=14torr and a Hillcoefficient=1.2. Calculate AYO2 for a climber with HbR assuming that, at 14,000 ft ( - 4300m), PO2=50mmHg in lungs and PO2=10mmHg in muscle capillaries.The arterial O₂ concentration is given by the following expression [0₂] = 0.003 P0₂ + (PO₂)².8 +(26) 2.8 1. ЗЧНЬ (Рог ) 2-8 Where Poz is the alveolar O₂ pressure and Hb is the hemoglobin concentration in g/dL, respectively A subject who is at 0-95 ATM (211-0₂) has an arterial O₂ concentration of 19ml/dL and and arterial CO₂ pressure of 38mm Hg. Also, VO₂ = 340mL/min.; VCD₂ = 289 mL/min. Therefore, your hemoglobine level is: A. 14.39 Idl 8. 14.8 g/dl C. 15.2 g/dl D. 15.7g/dL E. 16 g/dL
- A child weighing 22 lbs, has an infection and the doctor orders erythromycin drops 2.0 mLp.o. q6h. The bottle states that the usual dosage is 20.0-40.0 mg/kg/day, and there are35.0 mg per 1.5 mL. Find the min and max dosage per day in mL. Is the order within therecommended dosage?Below is an oxygen-binding curve for two hemoglobin variants. 1.0 0.8 0.6 B 0.4 0.2 20 40 60 80 100 O2 pressure (torr) Determine the p50 for variant A to the nearest 5 torr (i.e., if the p50 was 12, you would write 10). Determine the fraction of the hemoglobin B bound with O2 in the lungs (pO2 = 100 torr) that delivers oxygen to the tissues (pO2 = 20 torr)? Answer to the nearest 0.05 value (for example, 0.10 or 0.15). Which hemoglobin variant (write A or B or same) delivers more oxygen to tissues? Fraction bound with O2The following data describe the binding of oxygen to human myoglobin at 37 °C. Po, (mm Hg) Yo. Po, (mm Hg) Yo: 0.5 0.161 0.697 1 0.277 8. 0.754 2 0.434 12 0.821 3 0.535 20 0.885 0.605 From the se data, estimate (a) Pso and (b) the fraction saturation of myoglo- bin at 30 mm Hg, the partial pressure of Oz in venous blood. 4)
- Below is the oxygen saturation curve for myoglobin and hemoglobin at a pH of 7. The p50 for myoglobin is indicated by the dashed lines on the graph. Mb and Hb O2 saturation: pH 7 10 0.8 Myoglobin 0.6 P50 = 0.2 0.4 Hemoglobin 0.2 - 0.0 pO2 [kPa] Which of these molecules (Mb/Hb/neither or both) has cooperativity? [ Select ] What would you expect to happen to the p50 of myoglobin if the pH were decreased to a pH of 4? [ Select ] Fraction saturationIn a study of O2 uptake by muscle at high altitude, a physiologist prepares an atmosphere consisting of 79 mole % N2, 17 mole % 16O2, and 4.0 mole % 18O2. (The isotope 18O will be measured to determine O2 uptake.) The total pressure is 0.75 atm to simulate high altitude. Calculate the mole fraction and partial pressure of 18O2 in the mixture.2,3-bisphosphoglycerate (BPG) is a negative allosteric regulator of hemoglobin that is produced in red blood cells. Normally, red blood cell levels of BPG are 5 mmol/L, yielding curve 2. Individuals acclimated to high altitudes can have BPG levels of 8 mmol/L to optimize their oxygen utilization. Saturation 2 3 S Which curve represents hemoglobin of someone living at normal altitudes? 1 2 Pos (mm Hg) 3 None of the answers are correct 2 and 3
- VO2 calculation scenario: Body mass= 102 kg, HR= 180 beats/min, SV= 110 ml blood/beat, venous oxygen content = 4 ml O2/100 ml blood. What is the VO2 (ml O2/kg/min) for this scenario? (round to the nearest tenth). Remember your answer, as you will be asked to interpret this VO2 in another question. a. 31.1 b. 776.5 c. 3.5 d. 221.8 e. 7.8A forearm skeletal muscle has a hemoglobin concentration of 92 microM. An arterial occlusion of the upper arm determines a decrease in saturation at a rate of 15% per minute, and no change in blood volume. Find the muscle oxygen consumption in units of micromolo2/(100 mltissue-min).Inorganic compounds of metallic mercury are presumed from metabolic studies to distribute uniformly after inhalation or ingestion with 8% going to the liver and 92% to the total body. Biological clearance of mercury in each of these tissues occurs by two compartments, 95% with a biological half-life of 40 days and the remaining 5% with a biological half-life of 10,000 days. For an intake of 1 MBq of 203Hg (Tr= 46.61 d). Determine the following 1. Total number of transformations in the Liver. 2. Total number of transformations in the total body.