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- Muscle motor unit recruitment follows the pattern of the SO (I) fibers being recruited first followed by the FOG (IIa) and then ultimately by the FG (IIb) if and when workloads require this. Muscle fatigue follows the order that the FG fibers fatigue first, followed by the FOG fibers and finally (maybe never) the SO fibers. Explain how it makes sense physiologically that the last fibers to be recruited to contract are the first to fatigue, while the first fibers to be recruited to contract would be the last to fatigue.Why does muscle CAP Amp for both the normal Ringer's solution and Ringer's solution with Neostigmine increased as the stimulus amplitude increased, but a normal Ringer's solution would have a larger muscle CAP Amp value? Why is this the same case for a CAP Period as stimulus amplitude increases?. Why would Muscle CAP Period values for Ringer's with NEO then have larger values. Why does a normal Ringer's solution take longer to reach maximum action potential ?Briefly describe why contraction of the muscle cell is called “sliding filament theory” (what is sliding?) and what do we mean by “excitation-contraction coupling?” (What is being excited, and what is coupled?)
- Hill's equation gives a relation between muscle contraction rates νν and muscle tension TT (T+α)(ν+β)=(T0+α)β(T+α)(ν+β)=(T0+α)β for positive parameters αα and ββ and resting tension T0T0. Rewrite the equation so that the contraction rate is a function of tension.Does flexion or extension of the individual muscles affect the strength of EMG activity in either the Pronator or Biceps muscle during simulated arm wrestling?For the following five events, which is the correct sequence that describes the excitation and contraction of a skeletal muscle fiber? 1. Tropomyosin shifts, exposing the myosin-binding sites on actin. 2. Calcium is released from the sarcoplasmic reticulum and binds to the troponin complex. 3. An action potential is propagated down the transverse tubules. 4. Cycles of myosin cross-bridge formation and breakdown cause the thin filaments to slide toward the center of the sarcomere. 5. An action potential in a motor neuron causes the axon to release acetylcholine, which triggers an action potential in a muscle fiber. 1 → 2 → 3 → 4 → 5 3 → 2 → 4 → 1 → 5 2 → 1 → 3 → 5 → 4 5 → 3 → 2 → 1 → 4 4 → 3 → 1 → 2 → 5
- Explain how optimal skeletal muscle force (high muscle tension) can be achieved during a high intensity exercise. (Mention and explain how wave summation, motor recruitment summation, muscle length, and type of muscle fibers activated can affect muscle force).Explain the intracellular mechansim of smooth muscle relaxation of agaonist such as mepyrimine and atropine. Give diagram for each.The motor unit firing patterns are measured in a human hand muscle using an electromyography (EMG) recording. Which one of the following statements is the best description of the EMG pattern observed as the individual voluntarily attempts to make a low-level force of contraction in the muscle and steadily increases the force of contraction? Low amplitude spikes visible on the EMG trace at low force. Larger amplitude spikes become visible with increasing force of contraction. Low frequency of small amplitude spikes on the EMG trace at low force. Spike frequency and amplitude increase with increasing force. A large single deflection in the trace as the individual contracts the muscle. The deflection gets larger with increasing force. Low frequency of spikes on the EMG trace at low force. The frequency of spikes becomes more frequent with increasing force.
- Acetylcholine-gated cation channels at the neu-romuscular junction open in response to acetylcholinereleased by the nerve terminal and allow Na+ ions to enterthe muscle cell, which causes membrane depolarizationand ultimately leads to muscle contraction.A. Patch-clamp measurements show that young ratmuscles have cation channels that respond to acetylcho-line (Figure Q11–4). How many kinds of channel are there?How can you tell?B. For each kind of channel, calculate the number ofions that enter in one millisecond. (One ampere is a cur-rent of one coulomb per second; one pA equals 10–12ampere. An ion with a single charge such as Na+ carries acharge of 1.6 × 10–19 coulomb.)What are the variables of the PCSA and what are the tradeoffs of these parameters to muscle function? b. What are the muscle fiber orientations and why would the body choose one orientation over another?Define the all-or-none principle. The same student remarked that at 180 mV stimulus, it is expected that 100 g mass is lifted by the muscle fibre. Do you agree or disagree? Why or why not?