Without Inhibitor [substrate], mM 1 Rate (Vo), mM/min 0.997774599 With Inhibitor Rate (Vo), mM/min 0.847401 1.5 1.076855826 0.973852 2 1.122873947 1.037991 2.5 1.160626292 1.068431 3 1.184072485 1.105866
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Another member of your research group studied the kinetics of the
GAPDH from the organism. They also determined if the GAPDH from
the organism is also inhibited by the known inhibitor of GAPDH from
humans.
A. From the following data, determine the KM (Michaelis-Menten Constant) and the Vmax
(maximum velocity) of the enzyme without and with the inhibitor.
B. If GAPDH is inhibited, what specific type of inhibition is observed?
![Without Inhibitor
[substrate], mM
1
Rate (Vo), mM/min
0.997774599
With Inhibitor
Rate (Vo), mM/min
0.847401
1.5
1.076855826
0.973852
2
1.122873947
1.037991
2.5
1.160626292
1.068431
3
1.184072485
1.105866](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fce323461-c153-4290-9260-fdb6a91da9c6%2F19481c1c-f87b-4759-bb3d-22674159cc0f%2Fbo1o6wm_processed.png&w=3840&q=75)
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- Now answer the following questions: 1. Is this patient experiencing a disorder affecting anaerobic or aerobic metabolism? a) disorder affecting anaerobic metabolism. b) disorder affecting aerobic metabolism. c) None of them d) Both 2. You decide to perform assays to check the activity of one or more metabolic enzymes in the red blood cells. Which enzyme(s) would you check? a) Amylase b) Enzymes of pentose phosphate pathways c) Transaminase enzymes d) hexokinase, phosphofructokinase, and pyruvate kinase-Inhibitor +Inhibitor [S] (mM) Vη&νβσπ: (μmol/sec). ν0&νβσπ;&νβσπ:(μmol/sec) 0.0001 33 17 0.0005 71 50 0.001 83 67 0.005 96 91 0.01 98 95 What is the TYPE of iinhibitor?What is the medical diagnostic value associated with the presence of the following enzyme in the bloodstream? ALT