Enalaprilat is a competitive inhibitor of the angiotensin-converting enzyme (ACE), which cleaves the blood-pressure regulating peptide angiotensin I. ACE has a KM = 52 μM for angiotensin I, which is present in plasma at a concentration of 79 μM. When enalaprilat is present at 3.0 nM, the activity of ACE in plasma is 14 % of its uninhibited activity. What is the value of K₁ for enalaprilat? Express your answer to two significant figures and include the appropriate units.

Enalaprilat is a competitive inhibitor of the angiotensin-converting enzyme (ACE), which cleaves the blood-pressure regulating peptide angiotensin I. ACE has a KM = 52 μM for angiotensin I, which is present in plasma at a concentration of 79 μM. When enalaprilat is present at 3.0 nM, the activity of ACE in plasma is 14 % of its uninhibited activity. What is the value of K₁ for enalaprilat? Express your answer to two significant figures and include the appropriate units.

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter3: The Plasma Membrane And Membrane Potential

Section: Chapter Questions

Problem 1SQE: Using the Nernst equation, calculate the equilibrium potential for Ca2 and for C1 from the following...

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