Please don't provide handwriting solution Identifying isosteres; selecting isosteres. The structure of oxacillin, an antibiotic, is shown below with six differentanalogues involving an isosteric substitution.Which analogue involves a retroinverso peptide isostere?ACCH3CINHIZIоCH₂NHBixXо-S-OHOHBDSOH0-2oxacillinantibioticCH3CH3OIZIIsогонOHOHI

Retro-inverse peptide:1. The sequence of parent chain is reversed such that the N side to C side…

Answered: Which analogue involves a retroinverso…

Biochemistry

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ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

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NOTE: PLEASE SEND. CLEARER IMAGE PLEASE THANK YOU SOMUCH 2. Structural representation of tetrapeptide Phe-Met-Tyr-Asn
Be sure to answer all parts. Give the amino acid sequence of an octapeptide that contains the amino acids Lys, Pro, Tyr, Ile (2 equiv) , Gln, Trp, Phe, and forms the following fragments when partially hydrolyzed with HCl: Lys–Ile-Phe-Pro, Phe-Pro-Gln-Tyr, and Trp-Ile-Lys.
PRACTICE NAMING. Identify the number of amino acids, number of peptide bonds, and name the peptide. i.e. Ala-Cys • Dipeptide • 1 peptide bond • Alanylcysteine Cys-tyr-phe-gln-asn-cys-pro-arg-gly
me (1).docx BIU A A- are they different? 3. What are three ways that 2-deoxystreptamine (2-DOS) aminoglycosides can inhibit protein synthesis? 4. Chloramphenicol: a. Where does this drug bind? b. How does it inhibit protein synthesis?
Be sure to answer all parts. Give the amino acid sequence of an octapeptide that contains the amino acids Thr, Phe, Ile (2 equiv), Asp, Cys, Val, Leu, and forms the following fragments when partially hydrolyzed with HCl: Thr-Ile-Phe, Phe-Ile-Asp-Val, and Asp-Val-Cys-Leu.
what is lactose intolerance ? describe the molecular life cycle for this disease. also describe how it occurs in a molecular level detailed mechanism. what causes this disease and how it develops ? provide detailed biochemical phenomena and life cycle for Lactose Intolerance condition.
Pro-Ser-Ala-Phe-Glu. Draw this peptide at pH 7 and include its stereochemistry.
Peptides. 1. Draw the peptide Ala-Glu-Gly-Lys, as it would occur at physiological pH = 7.4. The R groups of Ala and Gly are not acidic or basic, therefore do not have a pka and the charge on these R groups is therefore independent of pH. Glu is acidic and Lys is basic, therefore the charge on these amino acids is pH dependent. The pKas are shown below. pKa N-term = 9.0 C-term = 3.5 Glu4.1 Lys = 10.5 2. Draw a circle around the peptide bonds. 3. Label the C-terminus and the N-terminus. 4. What is the overall charge on the peptide at pH 7.4?
Chymotrypsin digestion, separation of peptides, and Edmann technique give the sequences for peptide fragments as follows: C-1 G-A-E-A-T-E C-2 G-K-V-G-A-H-A-G-E-Y C-3 V-L-S-P-A-K-T-N-V-K-A-A-W What is the sequence for the peptide? NOTE: Label the fragments when reconstructing the peptide chain e.g. for trypsin T-1, T-2 etc...
Be sure to answer all parts. Draw the s-trans and s-cis conformations of the peptide bond in the dipeptide Ala-Ala. Be sure to show appropriate stereochemistry for the natural amino acid and the alkenes. I I I I I draw structure... s-trans draw structure ... s-cis
All statement true about solanaceous alkaloids except: solanaceous alkaloids are esters of the bicyclic aminoalcohol 3-hydroxytropane or of related aminoalcohols. have been modified by preparing other esters of 3-a-tropanol or making a quaternary of the nitrogen in tropanol or scopine with a methyl halide. The aminoalcohol derived from scopolamine, namely tropin, has the axial orientation of the 3-hydroxyl group but, in addition, a B-oriented epoxy group bridged across the 6,7 positions several different solanaceous alkaloids known, it has been indicated that (-)- hyoscyamine, atropine, and scopolamine are the most important.
Please help! Sketch a titration curve of the peptide Ala-Tyr-Gln-Met-Asp-His from pH=0 to 14 up to 5 equivalnets of KOH (Please type answer)

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Which analogue involves a retroinverso peptide isostere? CH₂ A с CH3 Ö G O NH FX NH S OH OH S B D S OH 0-2 oxacillin antibiotic CH₂ CH₂ IZ FO I I OH -OH